RNF2 抗体
Quick Overview for RNF2 抗体 (ABIN1449179)
抗原
See all RNF2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- This antibody reacts with Ring1B.
-
交叉反应 (详细)
- Species reactivity (tested):Human, Mouse, Hamster
-
纯化方法
- Protein-A Sepharose
-
免疫原
- GST fusion mouse full-length Ring1B protein
-
亚型
- IgG2b
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
-
储存液
- Without preservative
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- RNF2 (Ring Finger Protein 2 (RNF2))
-
别名
- RNF2
-
背景
- Polycomb-group (PcG) proteins form multimeric complexes that maintain the state of transcriptional repression of several regulatory genes during development. Ring1B/Rnf2 forms part of a protein complex containing other PcG proteins, such as Mel18, Bmi1, MBLR, MPc3, and the spliceosome protein Sap155, and these complexes associate with chromatin to regulate transcription. Ring1B may also play a role in the regulation of Hox gene expression by PcG complexes. Deletion of Ring1B activity results in gastrulation arrest and cell cycle inhibition.Synonyms: BAP-1, BAP1, DING, E3 ubiquitin-protein ligase RING2, HIP2-interacting protein 3, HIPI3, Protein DinG, RING finger protein 2, RING1B
-
基因ID
- 6045
-
NCBI登录号
- NP_009143
-
UniProt
- Q99496
抗原
-